Belkisa Colic-Hadzic, Nada Mladina, Devleta Hadzic, Elvira Konjic


Introduction: The aim of the present study was to indicate importance of early detection of primary immunodeficiency in children, to determine the type of disorders and apply profilaxis and therapy. Material and Methods: The study was retrospective- prospective, during the period from 01.01.1997 to 31.12.2007 at Pediatric clinik, University Clinical Centre Tuzla. Results and Discussion: There were 53 patients both genders, age 1 month to 12.7 years (average age 3.0±3.4). In 33 (62.4%) patients diagnosis of primary immunodeficinecy was estimated until 3. years of life, cellular imunodeficinency disorders was diagnosed in 1 (1.9%), humoral 47 (88.8%) and C3 complement deficit in 5 (9.3%) of our patients. Since 2004 we registrated in crease new diagnosed, which point we started with screening among patients with repeated infections. Therapy and prophilaxy was administrated according usualy guidelines for these disorders of imunity. Therapy result was different according to type disorders, child age, and previous infections. After treatment, 37 (70%) patients recovered, as same as in 9 (17%), the worse condition in 2 (4%), and death in 5 (9%). Conclusion: According to accepted incidence in generall population presented number of immunodefitienti patients in our region is not adekvate and intensive detection in future period is neccessary.


primary immunodeficiency; early detection; children

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DOI: 10.5457/ams.v37i2.8