Organ involvement in systemic sclerosis
Abstract
Introduction: In systemic sclerosis, several organ systems can be affected, due to the basic pathophysiological mechanism at the endothelial level.
Aim: The aim of this research is to show the frequency of clinical manifestations as well as their correlation in our sample of patients.
Methods: Twenty-nine patients with systemic sclerosis were included in our study. A correlation was made between clinical manifestations, parameters and organic involvement.
Results: The number of patients who had esophageal involvement was 16 (55.2%), cardiac involvement 18 (62.1%), pulmonary 27 (93.1%) and renal 16 (55.2%). The occurrence of esophageal, cardiac and renal involvement was statistically significant in correlation with disease duration (p=0.017, p=0.014; p=0.032). The appearance of digital ulcerations (DU) was significantly correlated with esophageal and cardiac involvement, p=0.034 and p=0.01. Reduction of renal involvement, decrease in creatinine clearance and thinning of the renal parenchyma, occurred simultaneously with cardiac involvement in a statistically significant correlation, p= 0.014 and p=0.011. The reduction in ejection fraction and the occurrence of diastolic dysfunction also affected renal involvement, p= 0.009 and p=0.017.
Conclusion: We showed a correlation between the duration of the disease and organic involvement, as well as DU with cardiac and esophageal involvement. The connection between the cardiac and renal systems affects the overall course of the disease and the higher mortality of patients. Therefore, with early detection, adequate management and therapeutic modalities can be accessed in a timely manner in order to prevent further complications of the course of the disease.
Keywords
References
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DOI: 10.5457/ams.v55i1.850
