THE IMPACT OF ANTI-INFLAMMATORY IMMUNE RESPONSE ON FATAL OUTCOME IN THE EARLY STAGE OF A COMPLICATED INTRA-ABDOMINAL INFECTION
Abstract
Background: There is still no study investigating the role of anti-inflammatory immune response in the early stage of a complicated intra-abdominal infection (cIAIs).
Aim: To evaluate its impact on unfavorable outcome using the already established anti-inflammatory biomarkers CD14+HLA-DR+ (mHLA-DR) and CD4+CD25+CD127low/neg (Tregs).
Methods: We conducted a single-center prospective study at University Hospital “Prof. Dr. Stoyan Kirkovich” Stara Zagora between November 2018 and August 2021 on 62 patients with cIAIs. We measured the perioperative expression levels of mHLA-DR and Tregs by flow cytometry.
Results: The mortality rate during hospital stay was 14.5%. We found no significant differences between survivors and non-survivors in the values of mHLA-DR (p = 0.061 and p = 0.13 pre- and postoperatively) and Tregs (p = 0.992 and p = 0.109 pre- and postoperatively). ROC Curve analysis revealed that neither mHLA-DR (AUROC = 0.682 and 0.72 pre- and postoperatively), nor Tregs (AUROC = 0.501 and 0.689) levels were able to prognosticate the outcome.
Conclusion: By 3rd POD the anti-inflammatory reaction is not directly responsible for the fatal outcome in patients with cIAIs.
Keywords
References
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DOI: 10.5457/ams.v54i2.822
