Innovative Diabetes Management: Navigating Treatment, Financial Constraints, and Patient-Centered Care
Abstract
Diabetes mellitus, a chronic and progressive disease, often leads to severe complications that compromise patients' quality of life and reduce life expectancy. This case study presents a 54-year-old female patient with type 2 diabetes mellitus, diagnosed 13 years ago, who experienced frequent hypoglycemia despite achieving satisfactory glycemic control. The patient's treatment regimen included basal-bolus insulin therapy, oral metformin, and rigorous self-monitoring of blood glucose, yet she expressed dissatisfaction with her weight and overall well-being. To address these concerns, liraglutide, a GLP-1 receptor agonist, was introduced into her treatment plan. Liraglutide was selected for its ability to maintain glycemic control, reduce hypoglycemic episodes, facilitate weight loss, and offer cardiovascular protection. Despite initial out-of-pocket costs due to lack of insurance coverage, the patient experienced a marked improvement in glycemic variability, reduced insulin dependence, decreased frequency of glucose monitoring, and weight reduction after just two months of therapy. Her treatment evolved with insurance coverage of GLP-1 receptor agonists, leading to a switch to dulaglutide. This case underscores the importance of individualized, holistic diabetes management that addresses glycemic control and prioritizes patient satisfaction and quality of life. It also highlights the impact of medication costs and insurance coverage on treatment accessibility and long-term outcomes.
Keywords
References
Komenda, P.; Ferguson, T.W.; Macdonald, K.; Rigatto, C.; Koolage, C.; Sood, M.M.; Tangri, N. Cost-effectiveness of primary screening for CKD: A systematic review. Am. J. Kidney Dis. 2014, 63, 789–797.
Steinke, J.M. The natural progression of kidney injury in young type 1 diabetic patients. Curr. Diab. Rep. 2009, 9, 473–479.
Bourne RRA, Jonas JB, Bron AM, Cicinelli MV, Das A, Flaxman SR, et al. Prevalence and causes of vision loss in high-income countries and Eastern and Central Europe in 2015: magnitude, temporal trends and projections. Br J Ophthalmol. 2018;102:575–585. doi: 10.1136/bjophthalmol-2017-311258.
Elisa Dal Canto, Antonio Ceriello, Lars Rydén, Marc Ferrini, Tina B Hansen, Oliver Schnell, Eberhard Standl, Joline WJ Beulens, Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications, European Journal of Preventive Cardiology, Volume 26, Issue 2_suppl, 1 December 2019, Pages 25–32, https://doi.org/10.1177/20474873198783715.
S.P. Marso, G.H. Daniels, K. Brown-Frandsen, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes New Engl. J. Med., 375 (4) (2016), pp. 311-322, 10.1056/NEJMoa1603827.
G Ferrannini, H.C Gerstein, H.M Colhoun, G.R Dagenais, R Diaz, L Dyal, M Lakshmanan, L Mellbin, J Probstfield, M.C Riddle, J.E Shaw, L Ryden, REWIND Investigators , Dulaglutide is cardioprotective with or without background metformin in patients with diabetes and established or high risk for coronary vascular disease. A subgroup analysis of the REWIND Trial, European Heart Journal, Volume 41, Issue Supplement_2, November 2020, ehaa946.3353, https://doi.org/10.1093/ehjci/ehaa946.3353.
Harris SB, Cheng AYY, Davies MJ, et al. Person-Centered, Outcomes-Driven Treatment: A New Paradigm for Type 2 Diabetes in Primary Care. Arlington (V.A.): American Diabetes Association; 2020 May. FIGURE 3, [Decision cycle for person-centered glycemic...]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559432/figure/F3/ doi: 10.2337/db2020-02.
American Diabetes Association Professional Practice Committee; Summary of Revisions: Standards of Care in Diabetes—2024. Diabetes Care 1 January 2024; 47 (Supplement_1): S5–S10. https://doi.org/10.2337/dc24-SREV.
DOI: 10.5457/ams.v55i1.821