Monitoring the response to non- adjuvant chemotherapy in patients with breast cancer using ultrasound: radiology pathology correlation
Abstract
Objective. The aim of this study was to determine whether there is a correlation between the size of ultrasound- measured malignant lesions in the breast in patients undergoing non- adjuvant chemotherapy using RECIST criteria and sizes of malignant lesions on definitive histopathological finding. Patients and methods. The study was retrospective study and was conducted on 32 women aged 37-69 years of age at the period of may 2017th until march 2019, mammograms and ultrasound suspected breast cancer (radiological findings is concludedObjective. The aim of this study was to determine whether there is a correlation between the size of ultrasound- measured malignant lesions in the breast in patients undergoing non- adjuvant chemotherapy using RECIST criteria and sizes of malignant lesions on dthe period of may 2017th until march 2019, mammograms and ultrasound suspected breast cancer (radiological findings is concluded as BI RADS 4 and 5) and needle biopsy under control of ultrasound confirmed the diagnosis of breast cancer. Patients with metastases present were excluded from the study. Response to non- adjuvant chemotherapy was followed by ultrasound after the third and sixth cycles, after sixth cycles the patients underwent surgery.
To calculate the correlation was used Pearson's correlation coefficient. The difference in the values of p less than 0.05 (p <0.05) was considered statistically significant. Results. Complete response according to RECIST criteria was ultrasonically detected in 33,33 % of patients with estrogen, progesterone negative, and HER2 positive cancers and 33,33% of patients with estrogen positive, progesterone and HER2 negative cancers which correlates with the histopathological complete response. Conclusion. There is a  correlation between ultrasound measured tumor lesions using RECIST criteria and measured tumor lesions on histopathological speci
To calculate the correlation was used Pearson's correlation coefficient. The difference in the values of p less than 0.05 (p <0.05) was considered statistically significant. Results. Complete response according to RECIST criteria was ultrasonically detected in 33,33 % of patients with estrogen, progesterone negative, and HER2 positive cancers and 33,33% of patients with estrogen positive, progesterone and HER2 negative cancers which correlates with the histopathological complete response. Conclusion. There is a  correlation between ultrasound measured tumor lesions using RECIST criteria and measured tumor lesions on histopathological speci
Keywords
Ultrasound, RECIST criteria, breast cancer, non-adjuvant chemotherapy.
DOI: 10.5457/ams.v51i1-2.558
