Prognostic significance(impact) of CD10protein expression in breast carcinoma

Abstract

Introduction: Although the breast carcinoma is more rare in age under thirthy years than older one, tendency of aggresive occurrance of disease in younger patients results with lower rate of survival. Even though the breast is considered as the most investigated tissue, predicting the course of disease and prognosis of outcome are uncertain.

The objectiv of conducted research was to determine CD10 oncoprotein expression in primary and recurrent breast carcinoma, and to investigate the dependence of C10 oncoprotein expreion in primary and recurrent breast carcinomm on the histologic and nuclear grade, expression of estrogen, progesteron and Her2/neu receptors, and to correlate the CD10 oncoprotein expression with occurring of breast carcinoma recurrence.

Patient and Methods: The study analyzed 64 patients with primary diagnosed invasive ductal (NST) breast carcinoma, stadium T1N0 and T2N0, in period from 2004 to 2008. The patients had at least five years of survival. The patients were divided into two groups, examine with diseas recurrence, and control without it.

Results: It has been found that age, histologic grade and absens of expression of estrogen and progesteron receptors are not in correlation with occurance of disease recurrence, but the nuclear grade and positiv expression of Her2/neu receptors are highly correlated. CD10 showed high statisticlly significant correlation with breast carcinoma recurrence.

Conclusion: Nuclear grade and positiv expression of Her2/neu receptors are highly correlating parameters with breast carcinoma recurrence as well as CD10 protein exprsion. CD10 is predictor of clinical course and outcome of breast carcinoma independently on the other parameters and can be conidered as the target of specific therapy.