Diagnostic value of serum inflammatory markers (Leucocyte count, C-reactive protein and neutrophil count) for detection of acute appendicitis in children
Aim: to evaluate diagnostic value leucocyte count, percentage of neutrophil count and CRP levels in detection of acute appendicitis in children.
Methods: We prospectively studied 112 consecutive patients, aged 0-15 years, who were referred to the outpatient pediatric department of our hospital with symptoms and signs of acute appendicitis, with intervals of less than 7 days from the onset, between October 01, 2010 and September 30, 2011. Predictors were values of leucocyte count, percentage of neutrophil count and CRP levels. Outcome measure was the PHD confirmation of acute appendicitis. Appendicitis-specific clinical and laboratory findings were done.
Results: We found a significant difference between the values of leukocytes to the PHD group findings (F = 17.46, df = 3, p <0.001). There were significant differences in the values of neutrophils by PHD diagnostic categories between groups of subjects (F = 18.87, df = 3, p <0.001). Values of C-reactive protein also in comparison between groups divided according to the findings of the PHD appendectomy, showed a statistically significant difference between groups (ANOVA, F = 13.67, df = 3, p <0.001).
Conclusion: In this study has been shown that Leucocyte count, C-reactive protein and neutrophil count are helpful tools to support the clinical diagnosis of all stages of appendicitis especially phlegmonous and perforated appendicitis in childhood.