D-DIMER AS A PARAMETER OF HYPERCOAGULABILITY IN LAPAROSCOPIC CHOLECYSTECTOMY

Authors

  • Sunita Delic Policlinic for Transfusiology, University Clinical Center Tuzla, Tuzla
  • Sabina Nuhbegovic Medical Faculty, University of Tuzla
  • Farid Ljuca Medical Faculty, University of Tuzla
  • Sefik Hasukic Department of Surgery, University Clinical Center Tuzla, Tuzla
  • Jasmina Petrov-Rasljic Policlinic for Transfusiology, University Clinical Center Tuzla, Tuzla
  • Svetlana Jovic Policlinic for Transfusiology, University Clinical Center Tuzla, Tuzla

DOI:

https://doi.org/10.5457/ams.v38i2.47

Keywords:

hemostasis, laparoscopic cholecystectomy, D-dimer, thromboembolism prevention

Abstract

Introduction: Laparoscopic cholecystectomy is a method of choice in the treatment of calculous gallbladder. There is a clear evidence of changes in hemostatic parameters during this surgical procedure, which can result in thromboembolic complications. The aim of the study was to evaluate changes in D-dimer values, as a marker of hypercoagulability in patients treated with laparoscopic cholecystectomy.

Patients and methods: The study included total of 60 patients, divided into two groups, one treated with classic (open) and other with laparoscopic method. Blood samples were taken from all patients before, during the surgery and 24 hours and 5 days after the procedure with consequent determination of D-dimer levels.

Results: Blood samples of patients in both groups manifested higher values of D-dimer during the operation, 24 hours and 5 days after the procedure. We have found elevated values of D-dimer 5 days after the surgery in the group of patients treated with laparoscopic cholecystectomy with 2.5 times higher levels compared to values measured preoperatively.

Conclusion: Our results suggest that there is an increased fibrinolytic activity after laparoscopic cholecystectomy, which demands more detailed and complete study on tromboembolism prophylaxis.

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Published

2009-06-18

Issue

Vol. 38 No. 2 (2009)

Section

Original papers

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