METASTATIC RENAL CELL ADENOCARCINOMA OF THE GALLBLADDER: A CASE REPORT
DOI:
https://doi.org/10.5457/ams.v38i1.39Keywords:
renal cell carcinoma, gallbladder metastases, surgeryAbstract
Background: Gallbladder (GB) involvement in patients with renal cell carcinoma (RCC) is extremely rare.
Case report: We present a report of a 58-year-old man with a metachronous metastatic contralateral renal cell adenocarcinoma of the gallbladder. The patient presented with the acute right upper quadrant pain and cholecystitis three years after resection of the primary renal neoplasm. Gallbladder tumor was detected clinically. The tumor was located in the fundus of the gallblladder under the lamina propria mucosa with subserosal invasion. Blood biochemistry results were in normal ranges as well as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (Ca 19-9). A histopathological examination revealed that the mucosal surface was covered with yellowish fibronecrotic tissue but contained no tumor cell. The tumor was located under the lamina propria mucosa with subserosal invasion. Tumor cells were positive for PAS, vimentin and CD 10, but negative for carcinoembryonic antigen (CEA), carbohydrate antigen (Ca 19-9) and cytokeratin 7 (CK7). Additional specific and immunohistochemical tests confirmed that gallbladder tumor was a metastasis of renal cell carcinoma. Renal cell adenocarcinoma was specified as Fuhrman's grade 2.
Conclusions: Pre-operative imaging studies are often futile for the differentiation between primary and secondary tumors of the gallbladder. Primary tumors of the gallbladder often coexist with gallstones while polypoid lesions in an acalculous gallbladder are frequently associated with metastasis.
Downloads
Published
Issue
Section
License
Copyright transfer
The listed authors warrant that they are the authors and sole owners of the submitted manuscript. The authors also warrant that the work is original; that it has not been previously published in print or electronic format and is not under consideration by another publisher or electronic medium; that it has not been previously transferred, assigned, or otherwise encumbered; and that the authors have full power to grant such rights. With respect to the results of this work, the manuscript of this or substantially similar content will not be submitted to any other journal until the review process in the Acta Medica Salinianana has been officially completed (acceptance or rejection of the manuscript). The paper will not be withdrawn from the review process by the Acta Medica Saliniana Editorial Board until the review process is completed. The authors will comply with the requests of the Acta Medica Saliniana Editors and reviewers to improve the paper for publication. The eventual disagreements will be submitted in a written form; the authors are aware that the disagreement(s) with the Acta Medica Saliniana requests may result in the rejection of the manuscript. The authors hereby grant to the Acta Medica Saliniana the right to edit, revise, abridge, and condense the manuscript. If the manuscript is accepted for publication in the Acta Medica Saliniana, the authors hereby transfer the copyright of the paper to the Acta Medica Saliniana. The authors permit the Acta Medica Saliniana to allow third parties to copy any part of the journal without asking for permission, provided that the reference to the source is given. For papers with more than one author: All other co-authors agree to allow the corresponding author to make decisions regarding prepublication release of the information in the paper to the media, federal agencies, or both.
