Is There an Association Between the Angiotensin Converting Enzyme Gene Polymorphism and Carotid Atherosclerosis in Non-Insulin-Dependent Diabetics?
DOI:
https://doi.org/10.5457/ams.v39i2.178Keywords:
angiotensin-coverting enzyme gene insertion/deletion polymorphism, non-insulin-dependent diabetes mellitus, atherosclerosis, carotid arteriesAbstract
Many studies have investigated the association between the angiotensin-coverting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and carotid intima-media thickness (ITM). However, only a few reports so far have studied carotid artery disease by plaque score in non-insulin-dependent diabetes mellitus (NIDDM) patients. To investigate the impact of genetic polymorphisms of the ACE on carotid atherosclerosis in the Slovenian population with NIDDM, we searched for the association between the ACE I/D gene polymorphism and either ITM or plaque score in subjects with NIDDM. Study participants were 292 NIDDM patients, randomly selected from one centre, with diabetes duration ≥ 10 years. The ITM and plaque score of the carotid arteries was determinated by bilateral B-mode ultrasonography. Polymerase chain reaction was used to evaluated the ACE I/D polymorphism. The frequency of the allele D was 55.3 %, and the frequency of the allele I was 44.7 %. The mean ITM was 1.08, 1.09 and 1.07 in the ACE DD, ID, and II genotypes, respectively. The ITM and the prevalence of focal plaque assessed by plaque score were not significantly different among the three genotypes in NIDDM patients. We may conclude that the ACE I/D gene polymorphism is not associated with ITM and plaque score. Therefore it could not be used as a genetic marker of carotid atherosclerosis in NIDDM patients.
Downloads
Published
Issue
Section
License
Copyright transfer
The listed authors warrant that they are the authors and sole owners of the submitted manuscript. The authors also warrant that the work is original; that it has not been previously published in print or electronic format and is not under consideration by another publisher or electronic medium; that it has not been previously transferred, assigned, or otherwise encumbered; and that the authors have full power to grant such rights. With respect to the results of this work, the manuscript of this or substantially similar content will not be submitted to any other journal until the review process in the Acta Medica Salinianana has been officially completed (acceptance or rejection of the manuscript). The paper will not be withdrawn from the review process by the Acta Medica Saliniana Editorial Board until the review process is completed. The authors will comply with the requests of the Acta Medica Saliniana Editors and reviewers to improve the paper for publication. The eventual disagreements will be submitted in a written form; the authors are aware that the disagreement(s) with the Acta Medica Saliniana requests may result in the rejection of the manuscript. The authors hereby grant to the Acta Medica Saliniana the right to edit, revise, abridge, and condense the manuscript. If the manuscript is accepted for publication in the Acta Medica Saliniana, the authors hereby transfer the copyright of the paper to the Acta Medica Saliniana. The authors permit the Acta Medica Saliniana to allow third parties to copy any part of the journal without asking for permission, provided that the reference to the source is given. For papers with more than one author: All other co-authors agree to allow the corresponding author to make decisions regarding prepublication release of the information in the paper to the media, federal agencies, or both.
