Association of Vitamin D with Lymphocyte Count and Calcium Levels in Patients with Sjögren Syndrome Patients
DOI:
https://doi.org/10.5457/ams.v54i2.761Keywords:
calcium serum, lymphocyte count, Sjögren syndrome, vitamin DAbstract
Background:
Previous studies have shown that there is a lower vitamin D levels in patients with Sjögren syndrome (SS) compared to healthy people. Lymphopenia is one of the frequent occurrences of SS, which is associated with the disease activity. However, there are limited that examine association between vitamin D levels, lymphocyte count, and serum calcium levels in patients with SS.
Aim:
This study aimed to determine association between vitamin D levels with lymphocyte count and calcium levels in patients with SS.
Methods:
A cross-sectional design that includes 24 outpatients with Sjögren syndrome (SS) was adopted at Dr. Moewardi General Hospital from January 2021 to December 2022. The ELFA method (ng/ml) was used to obtain the measurement of vitamin D levels while the flow cytometer method (%) was used to determine lymphocyte count. Calcium levels was determined using the ISE direct method (mmol/L) and the normality test uses Shapiro-Wilk, followed by the Spearman rank test.
Results:
Association between vitamin D and lymphocyte count in Sjögren syndrome (SS) patients was r = 0.066, with a p-value = 0.760 (p-value> 0.05). Furthermore, association between vitamin D and calcium levels in patients was r = -0.023 with a p-value = 0.914 (p-value> 0.05).
Conclusion:
In conclusion, vitamin D was not related to lymphocyte count and blood calcium levels in Sjögren syndrome (SS) patients.
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