Correlation between serum activity of liver enzymes and cognitive impairment in patients with Alzheimer's disease and vascular dementia

Authors

  • Orhan Lepara Department of Human Physiology, University of Sarajevo School of Medicine, Sarajevo, Bosnia and Herzegovina.
  • Miralem Musić Department of Pathophysiology, University of Sarajevo School of Medicine, Sarajevo, Bosnia and Herzegovina.
  • Asija Začiragić Department of Human Physiology, University of Sarajevo School of Medicine, Sarajevo, Bosnia and Herzegovina.
  • Almir Fajkić Department of Pathophysiology, University of Sarajevo School of Medicine, Sarajevo, Bosnia and Herzegovina.
  • Amela Derviš¡ević Department of Human Physiology, University of Sarajevo School of Medicine, Sarajevo, Bosnia and Herzegovina.
  • Alen Dš¾ubur Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Center Sarajevo, Bolnička 25, 71 000 Sarajevo, Bosnia and Herzegovina
  • Azra Durak Nalbantić Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Center Sarajevo, Bolnička 25, 71 000 Sarajevo, Bosnia and Herzegovina
  • Saida Ibragić Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

DOI:

https://doi.org/10.5457/ams.v51i1-2.582

Keywords:

Alzheimer’s disease, creatine kinase, cognitive impairment, liver enzymes, vascular dementia

Abstract

Background: Recent research attempts to bring metabolic changes that evolve with aging into the context of neurodegenerative diseases, including dementia. Peripheral levels of liver enzymes may therefore play a central role in explaining the metabolic dysfunctions in Alzheimer's disease (AD) and vascular dementia (VD).

Aim: The aim of this study was to determine the correlation between serum activity of creatine kinase and liver enzymes (ALT, AST, LDH, GGT, and ALP) and cognitive impairment in AD and VD. Methods: The subjects were classified as AD patients (n=30), VD patients (n=30) and controls (n=30). Further on, the cognitive functions of all subjects were assessed using the Montreal - Cognitive Assessment (MoCA) test.

Results: The obtained results showed significantly lower ALT activity in AD and VD patients compared to controls. The MoCA scores were found to be in positive correlation with serum CK and GGT activity in AD patients. Further research is required to elucidate causal pathways underlying the association between serum liver parameters and the pathophysiology of dementia.

 

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Published

2022-03-23

Issue

Vol. 51 No. 1-2 (2021)

Section

Original papers

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