THE EFFECT OF FLUTICASONE PROPIONATE ON NASAL ALLERGIC TEST VALUES IN PATIENTS WITH ALLERGIC RHINITIS

Abstract

ABSTRACT

House dust Nasal allergy test (NT) was administered to patients with allergic rhinitis in order to determine the effect of local corticosteroid therapy on the test value. This was a prospective study. The experimental group consisted of 102 patients diagnosed with allergic rhinitis, based on the guidelines set by Allergic Rhinitis and Its Impact on Asthma (ARIA). The experimental group was divided in two subgroups: Group A consisted of 51 subjects with allergic rhinitis treated with a topical corticosteroid therapy for three months prior to the initial testing. Group B consisted of 51 subjects with allergic rhinitis not previously treated with a topical corticosteroid therapy. All subjects underwent nasal allergy test (NT1) to house dust mix (house dust mite, Dermatophagoides pteronyssinus, Dermatophagoides farinae, cockroach). Subjects of group B applied Fluticasone propionate 50 mg 2x2 thrust through both nostrils for a month, followed by a break of 10 days. At this time, control allergy test (NT2) was administered.   Statistical analysis of group A and B, based on the results of NT1 and NT2, indicated that Fluticasone propionate affects the value of the NT. Group A exibited an increase in NT2 values, while group B showed a decrease in NT2 values.