In vitro antibacterial activity and ferric reducing antioxidant power of selected metal complexes with schiff bases derived from 2,2-dihydroxyinddane-1,3- dione and selected amino acids

Emir Horozić, Aleksandar Anti, Zerina Mujić, Kenan Brkić, Karla Pelemiš

Abstract


Research into the use of organometallic compounds as potential drugs is extremely popular and yields promising results. In this research, a group of organometallic compounds based on 2,2-dihydroxyindane-1,3-dione and selected amino acids (histidine and phenylalanine) was synthesized. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on reference bacterial strains from the ATCC collection. The reduction ability of the complex was examined by the FRAP method. The complexes showed significant inhibitory activity against gram-positive bacteria, with zones of inhibition ranging from 10-25 mm. Antioxidant capacity is also high, with FRAP values ranging from 1315.07-22038.7 µmol/L. These results indicate the potential of the synthesized complexes to be used as antibiotics and synthetic antioxidants. However, additional in vitro and in vivo studies are needed to determine their biological activity in more detail.


Keywords


organometallic compound, bioactivity, antibacterial agents, FRAP

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DOI: 10.5457/ams.v50i1-2.578