SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL SPIRO COMPOUNDS CONTAINING THIAZOLIDINONE AND 1,3,4-OXADIAZOLE MOIETIES

Aluru Raghavendra Guru Prasad, Kakarlapudi Ranga Raju, Badampudi Santosh Kumar, Lakshmana Rao Krishna Rao Ravindranath

Abstract


Introduction: During recent years, the microorganisms have developed resistance to the drugs. Therefore, there is an ever raising demand for new, potent, fast-acting antimicrobial drugs with low toxicity. Thiazolidinone and 1,3,4-oxadiazole nuclei have been incorporated  into wide variety of drugs  leading to wide spectrum of pharmacological activity.

 

Aim: To describe the synthetic strategy and structural characterization of some novel spiro compounds containing thiazolidinone and 1,3,4-oxadiazole moieties and pertaining antimicrobial evaluation. Structural characterization was done based on the elemental analysis, IR spectral, 1H NMR spectral and 13C NMR spectral data. The antimicrobial activity of the newly synthesized compounds were evaluated by cup plate method.

 

Conclusion: The spiro compounds with -OCH3, -Cl and -Br substituents, namely 7c, 7e and 7f displayed promising in-vitro antimicrobial activity.


Keywords


Synthesis, characterisation, thiazolidinone, 1,3,4-oxadiazole, antimicrobial activity.



DOI: 10.5457/ams.v44i1-2.328